Borane → Tert-butyl 4-fluoro-2-(hydroxymethyl)pyrrolidine-1-carboxylate

HRID 1119740Notes

Reaction equation

HRID 1119740 reaction equation
[BH3:17].[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH:9]([C:14](=[O:15])[OH:16])[CH2:10][CH:11]([F:13])[CH2:12]1.[CH2:18]1[O:19][CH2:20][CH2:21][CH2:22]1.[CH2:23]1[O:24][CH2:25][CH2:26][CH2:27]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH:9]([CH2:14][OH:15])[CH2:10][CH:11]([F:13])[CH2:12]1

Participants

4

Reactant 3

HCID 6331BoraneHCID 8028Tetrahydrofuran2×HCID 47125231-(Tert-butoxycarbonyl)-4-fluoropyrrolidine-2-carboxylic acid

Product 1

HCID 56973583Tert-butyl 4-fluoro-2-(hydroxymethyl)pyrrolidine-1-carboxylate

Sources & evidence

ORD record
ord-a2aa01f240a84fdaa1046f8b4a0db1bb
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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