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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1120052Generated: October 30, 2026

Bromide ion → 2-(3,5-Difluoro-4-(trifluoromethyl)phenyl)-1-(methoxy-carbonyl)piperidine-4-carboxylic acid

https://huagongshe.com/reaction/1120052

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBromide ionHCID 259—
ReactantWaterHCID 962—
ReactantAcetonitrileHCID 6342—
ReactantTriethylamineHCID 8471—
Reactanttert-Butyl methyl etherHCID 15413—
ReactantLithium ionHCID 28486—
ReactantDimethyl 2-(3,5-difluoro-4-(trifluoromethyl)phenyl)-piperidine-1,4-dicarboxylateHCID 66732303—
Product2-(3,5-Difluoro-4-(trifluoromethyl)phenyl)-1-(methoxy-carbonyl)piperidine-4-carboxylic acidHCID 66732192—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetTraining data from https://doi.org/10.1039/C8SC04228D (7/10)
ORD IDord-0657ac390a3c470cac2416fcb2f6a2ef
Source noteTraining data from https://doi.org/10.1039/C8SC04228D (7/10)