Bromide ion → 2-(3,5-Difluoro-4-(trifluoromethyl)phenyl)-1-(methoxy-carbonyl)piperidine-4-carboxylic acid
Reaction equation
[Br-:28].[C:36]([O:37][CH3:38])([CH3:39])([CH3:40])[CH3:41].[CH3:29][CH2:30][N:31]([CH2:32][CH3:33])[CH2:34][CH3:35].[CH3:42][C:43]#[N:44].[F:1][c:2]1[cH:3][c:4]([CH:13]2[N:14]([C:23](=[O:24])[O:25][CH3:26])[CH2:15][CH2:16][CH:17]([C:19](=[O:20])[O:21][CH3:22])[CH2:18]2)[cH:5][c:6]([F:12])[c:7]1[C:8]([F:9])([F:10])[F:11].[Li+:27].[OH2:45]>>[F:1][c:2]1[cH:3][c:4]([CH:13]2[N:14]([C:23](=[O:24])[O:25][CH3:26])[CH2:15][CH2:16][CH:17]([C:19](=[O:20])[OH:21])[CH2:18]2)[cH:5][c:6]([F:12])[c:7]1[C:8]([F:9])([F:10])[F:11]Participants
8
Reactant 7
Product 1
Sources & evidence
- ORD record
- ord-0657ac390a3c470cac2416fcb2f6a2ef
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (7/10)
Reaction notes
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