Potassium Cation → 2,3′-Difluoro-4-methoxy-1,1′-biphenyl

HRID 1120546Notes

Reaction equation

HRID 1120546 reaction equation
[C:16](=[O:17])([O-:18])[O-:19].[CH3:27][I:28].[CH3:29][c:30]1[cH:31][cH:32][cH:33][cH:34][cH:35]1.[F:1][c:2]1[c:3](-[c:9]2[cH:10][c:11]([F:15])[cH:12][cH:13][cH:14]2)[cH:4][cH:5][c:6]([OH:8])[cH:7]1.[K+:20].[K+:21].[O:22]=[CH:23][N:24]([CH3:25])[CH3:26]>>[F:1][c:2]1[c:3](-[c:9]2[cH:10][c:11]([F:15])[cH:12][cH:13][cH:14]2)[cH:4][cH:5][c:6]([O:8][CH3:16])[cH:7]1

Participants

7

Reactant 6

HCID 813Potassium Cation2×HCID 1140TolueneHCID 6228DimethylformamideHCID 6328Methyl iodideHCID 19660Carbonate IonHCID 463126562,3'-Difluoro[1,1'-biphenyl]-4-ol

Product 1

HCID 463122202,3′-Difluoro-4-methoxy-1,1′-biphenyl

Sources & evidence

ORD record
ord-06a056846298425da902b3c9cf94384c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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