Methyl chloroformate → tert-butyl 4-(2,2-dimethylbutyl)-2-{2-[4-(5-fluoropyridin-2-yl)phenyl]-1-[(methoxy carbonyl)amino]ethyl}-1H-imidazole-1-carboxylate

HRID 1120681Notes

Reaction equation

HRID 1120681 reaction equation
[CH3:1][CH2:2][N:3]([CH2:4][CH3:5])[CH2:6][CH3:7].[Cl:8][C:9](=[O:10])[O:11][CH3:12].[NH2:13][CH:14]([CH2:15][c:16]1[cH:17][cH:18][c:19](-[c:22]2[n:23][cH:24][c:25]([F:28])[cH:26][cH:27]2)[cH:20][cH:21]1)[c:29]1[n:30]([C:40](=[O:41])[O:42][C:43]([CH3:44])([CH3:45])[CH3:46])[cH:31][c:32]([CH2:34][C:35]([CH2:36][CH3:37])([CH3:38])[CH3:39])[n:33]1>>[C:9](=[O:10])([O:11][CH3:12])[NH:13][CH:14]([CH2:15][c:16]1[cH:17][cH:18][c:19](-[c:22]2[n:23][cH:24][c:25]([F:28])[cH:26][cH:27]2)[cH:20][cH:21]1)[c:29]1[n:30]([C:40](=[O:41])[O:42][C:43]([CH3:44])([CH3:45])[CH3:46])[cH:31][c:32]([CH2:34][C:35]([CH2:36][CH3:37])([CH3:38])[CH3:39])[n:33]1

Participants

4

Reactant 3

HCID 6586Methyl chloroformateHCID 8471TriethylamineHCID 66705676tert-butyl 2-{1-amino-2-[4-(5-fluoropyridin-2-yl)phenyl]ethyl}-4-(2,2-dimethylbutyl)-1H-imidazole-1-carboxylate

Product 1

HCID 66705856tert-butyl 4-(2,2-dimethylbutyl)-2-{2-[4-(5-fluoropyridin-2-yl)phenyl]-1-[(methoxy carbonyl)amino]ethyl}-1H-imidazole-1-carboxylate

Sources & evidence

ORD record
ord-751ba1f5d6434508a12211ba909ea778
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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