Dichloromethane → 4-[4-[5-(1-Phenylcyclopropyl)-[1,3]thiazolo[5,4-b]pyridin-2-yl]phenoxy]pyrrolidine-2-carboxylic acid

HRID 1121080Notes

Reaction equation

HRID 1121080 reaction equation
[C:8]([O:9][C:10](=[O:11])[N:15]1[CH:16]([C:45](=[O:46])[OH:47])[CH2:17][CH:18]([O:20][c:21]2[cH:22][cH:23][c:24](-[c:27]3[s:28][c:29]4[n:30][c:31]([C:36]5([c:39]6[cH:40][cH:41][cH:42][cH:43][cH:44]6)[CH2:37][CH2:38]5)[cH:32][cH:33][c:34]4[n:35]3)[cH:25][cH:26]2)[CH2:19]1)([CH3:12])([CH3:13])[CH3:14].[Cl:48][CH2:49][Cl:50].[F:1][C:2]([F:3])([F:4])[C:5]([OH:6])=[O:7]>>[NH:15]1[CH:16]([C:45](=[O:46])[OH:47])[CH2:17][CH:18]([O:20][c:21]2[cH:22][cH:23][c:24](-[c:27]3[s:28][c:29]4[n:30][c:31]([C:36]5([c:39]6[cH:40][cH:41][cH:42][cH:43][cH:44]6)[CH2:37][CH2:38]5)[cH:32][cH:33][c:34]4[n:35]3)[cH:25][cH:26]2)[CH2:19]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 178452410HCID 178452410, compound

Product 1

HCID 671117394-[4-[5-(1-Phenylcyclopropyl)-[1,3]thiazolo[5,4-b]pyridin-2-yl]phenoxy]pyrrolidine-2-carboxylic acid

Sources & evidence

ORD record
ord-ec8267e21edf4fd69b59426b305d4321
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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