Dimethylformamide → tert-butyl 2-[4-(1,3-oxazol-5-yl)anilino]-4-(oxolan-2-ylmethylamino)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxylate

HRID 1121405Notes

Reaction equation

HRID 1121405 reaction equation
[O:38]1[CH:39]([CH2:43][NH2:44])[CH2:40][CH2:41][CH2:42]1.[O:45]=[CH:46][N:47]([CH3:48])[CH3:49].[o:1]1[cH:2][n:3][cH:4][c:5]1-[c:6]1[cH:7][cH:8][c:9]([NH:12][c:13]2[n:14][c:15]([O:30][S:31]([C:32]([F:33])([F:34])[F:35])(=[O:36])=[O:37])[c:16]3[c:17]([n:18]2)[CH2:19][CH2:20][N:21]([C:23](=[O:24])[O:25][C:26]([CH3:27])([CH3:28])[CH3:29])[CH2:22]3)[cH:10][cH:11]1>>[o:1]1[cH:2][n:3][cH:4][c:5]1-[c:6]1[cH:7][cH:8][c:9]([NH:12][c:13]2[n:14][c:15]([NH:44][CH2:43][CH:39]3[O:38][CH2:42][CH2:41][CH2:40]3)[c:16]3[c:17]([n:18]2)[CH2:19][CH2:20][N:21]([C:23](=[O:24])[O:25][C:26]([CH3:27])([CH3:28])[CH3:29])[CH2:22]3)[cH:10][cH:11]1

Participants

4

Reactant 3

HCID 6228DimethylformamideHCID 253298TetrahydrofurfurylamineHCID 59333731tert-butyl 2-(4-(oxazol-5-yl)phenylamino)-4-(trifluoromethylsulfonyloxy)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate

Product 1

HCID 59333769tert-butyl 2-[4-(1,3-oxazol-5-yl)anilino]-4-(oxolan-2-ylmethylamino)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxylate

Sources & evidence

ORD record
ord-592374bdd4b34a7e8d2b99fbd90818d0
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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