Hydrochloric Acid → Methyl 4-bromo-3-[2-[(2-methylpropan-2-yl)oxy]-2-oxoethoxy]-5-[3-[(1-methylsulfonylpiperidin-4-yl)methylamino]phenyl]thiophene-2-carboxylate

HRID 1121653Notes

Reaction equation

HRID 1121653 reaction equation
[C:2]([O:3][C:4](=[O:5])[N:9]1[CH2:10][CH2:11][CH:12]([CH2:15][NH:16][c:17]2[cH:18][c:19](-[c:23]3[s:24][c:25]([C:38](=[O:39])[O:40][CH3:41])[c:26]([O:29][CH2:30][C:31](=[O:32])[O:33][C:34]([CH3:35])([CH3:36])[CH3:37])[c:27]3[Br:28])[cH:20][cH:21][cH:22]2)[CH2:13][CH2:14]1)([CH3:6])([CH3:7])[CH3:8].[C:50](=[O:51])([OH:52])[O-:53].[CH3:42][S:43]([Cl:44])(=[O:45])=[O:46].[Cl:47][CH2:48][Cl:49].[ClH:1].[Na+:54]>>[N:9]1([S:43]([CH3:42])(=[O:45])=[O:46])[CH2:10][CH2:11][CH:12]([CH2:15][NH:16][c:17]2[cH:18][c:19](-[c:23]3[s:24][c:25]([C:38](=[O:39])[O:40][CH3:41])[c:26]([O:29][CH2:30][C:31](=[O:32])[O:33][C:34]([CH3:35])([CH3:36])[CH3:37])[c:27]3[Br:28])[cH:20][cH:21][cH:22]2)[CH2:13][CH2:14]1

Participants

7

Reactant 6

HCID 313Hydrochloric AcidHCID 769Bicarbonate IonHCID 923Sodium ionHCID 6344DichloromethaneHCID 31297Methanesulfonyl chlorideHCID 17759781HCID 17759781, compound

Product 1

HCID 68833651Methyl 4-bromo-3-[2-[(2-methylpropan-2-yl)oxy]-2-oxoethoxy]-5-[3-[(1-methylsulfonylpiperidin-4-yl)methylamino]phenyl]thiophene-2-carboxylate

Sources & evidence

ORD record
ord-133ff9473fa944a58137831b4adfa0cc
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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