Dichloromethane → Ethyl 4-(2-oxo-1,4-dihydropyrido[4,3-d]pyrimidin-3(2H)-yl)piperidine-1-carboxylate

HRID 1122571Notes

Reaction equation

HRID 1122571 reaction equation
[C:35]([c:36]1[nH:37][cH:38][cH:39][n:40]1)([c:41]1[nH:42][cH:43][cH:44][n:45]1)=[O:46].[C:8]([CH3:10])([CH3:11])([O:12][C:13](=[O:9])[NH:15][c:16]1[c:17]([CH2:22][NH:23][CH:24]2[CH2:25][CH2:26][N:27]([C:30](=[O:31])[O:32][CH2:33][CH3:34])[CH2:28][CH2:29]2)[cH:18][n:19][cH:20][cH:21]1)[CH3:14].[Cl:47][CH2:48][Cl:49].[OH:1][C:2]([C:3]([F:4])([F:5])[F:6])=[O:7]>>[O:12]=[C:13]1[NH:15][c:16]2[c:17]([cH:18][n:19][cH:20][cH:21]2)[CH2:22][N:23]1[CH:24]1[CH2:25][CH2:26][N:27]([C:30](=[O:31])[O:32][CH2:33][CH3:34])[CH2:28][CH2:29]1

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 5250894Bis-(1H-imidazol-2-YL)-methanoneHCID 22293255Ethyl 4-[(4-[(tert-butoxycarbonyl)amino]pyridin-3-yl methyl)amino]piperidine-1-carboxylate

Product 1

HCID 22293216Ethyl 4-(2-oxo-1,4-dihydropyrido[4,3-d]pyrimidin-3(2H)-yl)piperidine-1-carboxylate

Sources & evidence

ORD record
ord-767b19fa33934947a69f535e25078bb9
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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