Bromoform → 2-Bromo-7-chloro-5-((2,3-difluorobenzyl)thio)thiazolo[4,5-d]pyrimidine

HRID 1122611Notes

Reaction equation

HRID 1122611 reaction equation
[CH:29]([Br:30])([Br:31])[Br:32].[Cl:1][c:2]1[c:3]2[c:4]([n:5][c:6]([S:8][CH2:9][c:10]3[c:11]([F:17])[c:12]([F:16])[cH:13][cH:14][cH:15]3)[n:7]1)[n:18][c:19]([NH2:21])[s:20]2.[N:22]([O:23][C:24]([CH3:25])([CH3:26])[CH3:27])=[O:28]>>[Cl:1][c:2]1[c:3]2[c:4]([n:5][c:6]([S:8][CH2:9][c:10]3[c:11]([F:17])[c:12]([F:16])[cH:13][cH:14][cH:15]3)[n:7]1)[n:18][c:19]([Br:30])[s:20]2

Participants

4

Reactant 3

HCID 5558BromoformHCID 10906Tert-Butyl nitriteHCID 112216507-Chloro-5-[[(2,3-difluorophenyl)methyl]thio]-thiazolo[4,5-d]pyrimidin-2-amine

Product 1

HCID 226713342-Bromo-7-chloro-5-((2,3-difluorobenzyl)thio)thiazolo[4,5-d]pyrimidine

Sources & evidence

ORD record
ord-d1fd894c5be14574b7d1201ed20b9a48
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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