Dichloromethane → 5-chloro-N2-(4-(1-(3-chloropropylsulfonyl)piperidin-4-yl)-2,5-dimethylphenyl)-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine

HRID 1123834Notes

Reaction equation

HRID 1123834 reaction equation
[CH3:38][CH2:39][O:40][C:41]([CH3:42])=[O:43].[Cl:1][c:2]1[c:3]([NH:23][c:24]2[n:25][nH:26][c:27]([CH3:29])[cH:28]2)[n:4][c:5]([NH:8][c:9]2[c:10]([CH3:22])[cH:11][c:12]([CH:16]3[CH2:17][CH2:18][NH:19][CH2:20][CH2:21]3)[c:13]([CH3:15])[cH:14]2)[n:6][cH:7]1.[Cl:30][CH2:31][CH2:32][CH2:33][S:34](=[O:35])(=[O:36])[Cl:37].[Cl:44][CH2:45][Cl:46]>>[Cl:1][c:2]1[c:3]([NH:23][c:24]2[n:25][nH:26][c:27]([CH3:29])[cH:28]2)[n:4][c:5]([NH:8][c:9]2[c:10]([CH3:22])[cH:11][c:12]([CH:16]3[CH2:17][CH2:18][N:19]([S:34]([CH2:33][CH2:32][CH2:31][Cl:30])(=[O:35])=[O:36])[CH2:20][CH2:21]3)[c:13]([CH3:15])[cH:14]2)[n:6][cH:7]1

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 8857Ethyl AcetateHCID 154103-Chloropropanesulphonyl chlorideHCID 582549005-chloro-N-(2,5-dimethyl-4-(piperidin-4-yl)phenyl)-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine

Product 1

HCID 671555715-chloro-N2-(4-(1-(3-chloropropylsulfonyl)piperidin-4-yl)-2,5-dimethylphenyl)-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine

Sources & evidence

ORD record
ord-014771b9c4ed49e7b3e3fde95c516d47
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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