Dichloromethane → 1-(3-Fluoro-4-(2-(5-((2-methoxyethylamino)methyl)pyridin-2-yl)thieno[3,2-b]pyridine-7-yloxy)phenyl)urea

HRID 1124067Notes

Reaction equation

HRID 1124067 reaction equation
[Cl:48][CH2:49][Cl:50].[F:1][c:2]1[c:3]([O:4][c:5]2[c:6]3[c:7]([n:8][cH:9][cH:10]2)[cH:11][c:12](-[c:14]2[cH:15][cH:16][c:17]([CH2:20][N:21]([C:22](=[O:23])[O:24][C:25]([CH3:26])([CH3:27])[CH3:28])[CH2:29][CH2:30][O:31][CH3:32])[cH:18][n:19]2)[s:13]3)[cH:33][cH:34][c:35]([NH:37][C:38](=[O:39])[NH2:40])[cH:36]1.[F:41][C:42]([F:43])([F:44])[C:45]([OH:46])=[O:47]>>[F:1][c:2]1[c:3]([O:4][c:5]2[c:6]3[c:7]([n:8][cH:9][cH:10]2)[cH:11][c:12](-[c:14]2[cH:15][cH:16][c:17]([CH2:20][NH:21][CH2:29][CH2:30][O:31][CH3:32])[cH:18][n:19]2)[s:13]3)[cH:33][cH:34][c:35]([NH:37][C:38](=[O:39])[NH2:40])[cH:36]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 57919596Tert-butyl (6-(7-(2-fluoro-4-ureidophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl(2-methoxyethyl)carbamate

Product 1

HCID 252699051-(3-Fluoro-4-(2-(5-((2-methoxyethylamino)methyl)pyridin-2-yl)thieno[3,2-b]pyridine-7-yloxy)phenyl)urea

Sources & evidence

ORD record
ord-8790ca7a962e4821a6fb3f0bd37c42ec
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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