Hydrochloric Acid → tert-butyl 8-[[3-[4-(4-cyanophenyl)phenyl]-1-methoxy-1-oxopropan-2-yl]carbamoyl]-3-[4-[(3,4-dichlorophenyl)methoxy]phenyl]-3,6,8,9-tetrahydro-2H-[1,4]dioxino[2,3-g]isoquinoline-7-carboxylate
Reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][c:10]2[cH:11][c:12]3[c:13]([cH:14][c:15]2[CH2:16][CH:17]1[C:18](=[O:19])[OH:20])[O:21][CH2:22][CH:23]([c:25]1[cH:26][cH:27][c:28]([O:31][CH2:32][c:33]2[cH:34][c:35]([Cl:40])[c:36]([Cl:39])[cH:37][cH:38]2)[cH:29][cH:30]1)[O:24]3.[CH3:42][O:43][C:44]([CH:45]([CH2:46][c:47]1[cH:48][cH:49][c:50](-[c:53]2[cH:54][cH:55][c:56]([C:59]#[N:60])[cH:57][cH:58]2)[cH:51][cH:52]1)[NH2:61])=[O:62].[ClH:41]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][c:10]2[cH:11][c:12]3[c:13]([cH:14][c:15]2[CH2:16][CH:17]1[C:18](=[O:20])[NH:61][CH:45]([C:44]([O:43][CH3:42])=[O:62])[CH2:46][c:47]1[cH:48][cH:49][c:50](-[c:53]2[cH:54][cH:55][c:56]([C:59]#[N:60])[cH:57][cH:58]2)[cH:51][cH:52]1)[O:21][CH2:22][CH:23]([c:25]1[cH:26][cH:27][c:28]([O:31][CH2:32][c:33]2[cH:34][c:35]([Cl:40])[c:36]([Cl:39])[cH:37][cH:38]2)[cH:29][cH:30]1)[O:24]3Participants
4
Reactant 3
Product 1
Sources & evidence
- ORD record
- ord-3bf5da0f90694908b1143e83b75f5911
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (7/10)
Reaction notes
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