Methyl chloroformate → Methyl 3-[[4-(4-fluorophenyl)piperidin-1-yl]methyl]-4-thiophen-3-ylpyrrolidine-1-carboxylate

HRID 1124266Notes

Reaction equation

HRID 1124266 reaction equation
[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:8]1[CH2:9][CH:10]([CH2:18][N:19]2[CH2:20][CH2:21][CH:22]([c:25]3[cH:26][cH:27][c:28]([F:31])[cH:29][cH:30]3)[CH2:23][CH2:24]2)[CH:11]([c:13]2[cH:14][s:15][cH:16][cH:17]2)[CH2:12]1.[CH2:37]1[O:38][CH2:39][CH2:40][CH2:41]1.[CH3:32][O:33][C:34](=[O:35])[Cl:36]>>[N:8]1([C:34]([O:33][CH3:32])=[O:35])[CH2:9][CH:10]([CH2:18][N:19]2[CH2:20][CH2:21][CH:22]([c:25]3[cH:26][cH:27][c:28]([F:31])[cH:29][cH:30]3)[CH2:23][CH2:24]2)[CH:11]([c:13]2[cH:14][s:15][cH:16][cH:17]2)[CH2:12]1

Participants

4

Reactant 3

HCID 6586Methyl chloroformateHCID 8028TetrahydrofuranHCID 183647391-Benzyl-3-(RS)-(4-(4-fluorophenyl)piperidinylmethyl)-4-(RS)-(3-thienyl)pyrrolidine

Product 1

HCID 18364738Methyl 3-[[4-(4-fluorophenyl)piperidin-1-yl]methyl]-4-thiophen-3-ylpyrrolidine-1-carboxylate

Sources & evidence

ORD record
ord-bc03351438cc4c2cb6b35b5a12c8fd79
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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