Sodium ion → N-[6-(4-pyridyl)-1-[[2-(trimethylsilyl)ethoxy]methyl]-1H-indazol-3-yl]butanamide

HRID 1124828Notes

Reaction equation

HRID 1124828 reaction equation
[CH3:130][CH2:131][O:132][C:133](=[O:134])[CH3:135].[CH3:14][C:15]1([CH3:16])[C:17]([CH3:18])([CH3:19])[O:20][B:21]([c:22]2[cH:23][cH:24][c:25]3[c:26]([NH:39][C:40]([CH2:41][CH2:42][CH3:43])=[O:44])[n:27][n:28]([CH2:31][O:32][CH2:33][CH2:34][Si:35]([CH3:36])([CH3:37])[CH3:38])[c:29]3[cH:30]2)[O:45]1.[I:1][c:2]1[cH:3][cH:4][n:5][cH:6][cH:7]1.[Na+:8].[Na+:9].[O-:10][C:11](=[O:12])[O-:13].[O:46]1[CH2:47][CH2:48][O:49][CH2:50][CH2:51]1.[OH2:129].[cH:52]1[cH:53][cH:54][c:55]([P:56]([Pd:57]([P:58]([c:59]2[cH:60][cH:61][cH:62][cH:63][cH:64]2)([c:65]2[cH:66][cH:67][cH:68][cH:69][cH:70]2)[c:71]2[cH:72][cH:73][cH:74][cH:75][cH:76]2)([P:77]([c:78]2[cH:79][cH:80][cH:81][cH:82][cH:83]2)([c:84]2[cH:85][cH:86][cH:87][cH:88][cH:89]2)[c:90]2[cH:91][cH:92][cH:93][cH:94][cH:95]2)[P:96]([c:97]2[cH:98][cH:99][cH:100][cH:101][cH:102]2)([c:103]2[cH:104][cH:105][cH:106][cH:107][cH:108]2)[c:109]2[cH:110][cH:111][cH:112][cH:113][cH:114]2)([c:115]2[cH:116][cH:117][cH:118][cH:119][cH:120]2)[c:121]2[cH:122][cH:123][cH:124][cH:125][cH:126]2)[cH:127][cH:128]1>>[c:2]1(-[c:22]2[cH:23][cH:24][c:25]3[c:26]([NH:39][C:40]([CH2:41][CH2:42][CH3:43])=[O:44])[n:27][n:28]([CH2:31][O:32][CH2:33][CH2:34][Si:35]([CH3:36])([CH3:37])[CH3:38])[c:29]3[cH:30]2)[cH:3][cH:4][n:5][cH:6][cH:7]1

Participants

9

Reactant 8

HCID 923Sodium ion2×HCID 962WaterHCID 8857Ethyl AcetateHCID 19660Carbonate IonHCID 312751,4-DioxaneHCID 6094924-IodopyridineHCID 22319493N-[6-(4,4,5,5-tetramethyl [1,3,2]dioxaborolan-2-yl)-1-[[2-(trimethylsilyl)ethoxy]methyl]-1H-indazol-3-yl]butanamideHCID 178420554HCID 178420554, compound

Product 1

HCID 22319546N-[6-(4-pyridyl)-1-[[2-(trimethylsilyl)ethoxy]methyl]-1H-indazol-3-yl]butanamide

Sources & evidence

ORD record
ord-6509190e3bb649838a13c09b561e4d31
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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