Dimethyl Sulfoxide → N-((1-(4-(4-acetamido-2-oxopyrimidin-1(2H)-yl)phenyl)-1H-imidazol-4-yl)methyl)-5-chlorothiophene-2-carboxamide

HRID 1125083Notes

Reaction equation

HRID 1125083 reaction equation
[C:23]([CH3:24])(=[O:25])[NH:26][c:27]1[n:28][c:29](=[O:33])[nH:30][cH:31][cH:32]1.[CH3:51][S:52]([CH3:53])=[O:54].[Cl:1][c:2]1[cH:3][cH:4][c:5]([C:7](=[O:8])[NH:9][CH2:10][c:11]2[n:12][cH:13][n:14](-[c:16]3[cH:17][cH:18][c:19]([I:22])[cH:20][cH:21]3)[cH:15]2)[s:6]1.[Cu:55][I:56].[K+:45].[K+:46].[O-:47][C:48]([O-:49])=[O:50].[OH:34][c:35]1[cH:36][cH:37][cH:38][c:39]2[c:40]1[n:41][cH:42][cH:43][cH:44]2>>[Cl:1][c:2]1[cH:3][cH:4][c:5]([C:7](=[O:8])[NH:9][CH2:10][c:11]2[n:12][cH:13][n:14](-[c:16]3[cH:17][cH:18][c:19](-[n:30]4[c:29](=[O:33])[n:28][c:27]([NH:26][C:23]([CH3:24])=[O:25])[cH:32][cH:31]4)[cH:20][cH:21]3)[cH:15]2)[s:6]1

Participants

8

Reactant 7

HCID 679Dimethyl SulfoxideHCID 813Potassium Cation2×HCID 19238-HydroxyquinolineHCID 19660Carbonate IonHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 249868975-Chloro-N-((1-(4-iodophenyl)-1H-imidazol-4-yl)methyl)thiophene-2-carboxamideHCID 178474340HCID 178474340, compound

Product 1

HCID 24760162N-((1-(4-(4-acetamido-2-oxopyrimidin-1(2H)-yl)phenyl)-1H-imidazol-4-yl)methyl)-5-chlorothiophene-2-carboxamide

Sources & evidence

ORD record
ord-c9319df820ca45e8a9f0d853852c109a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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