Sodium ion → 7-Chloro-3-(2-chloro-pyridin-4-yl)-imidazo[1,2-a]pyridine

HRID 1125099Notes

Reaction equation

HRID 1125099 reaction equation
[Br:1][c:2]1[cH:3][n:4][c:5]2[n:6]1[cH:7][cH:8][c:9]([Cl:11])[cH:10]2.[C:23](=[O:24])([O-:25])[O-:26].[CH3:29][O:30][CH2:31][CH2:32][O:33][CH3:34].[Cl:12][c:13]1[n:14][cH:15][cH:16][c:17]([B:19]([OH:20])[OH:21])[cH:18]1.[Na+:27].[Na+:28].[OH2:22].[Pd:35]([Cl:36])[Cl:37].[c:38]1([P:39]([c:40]2[cH:41][cH:42][cH:43][cH:44][cH:45]2)[c:46]2[cH:47][cH:48][cH:49][cH:50][cH:51]2)[cH:52][cH:53][cH:54][cH:55][cH:56]1.[c:57]1([P:58]([c:59]2[cH:60][cH:61][cH:62][cH:63][cH:64]2)[c:65]2[cH:66][cH:67][cH:68][cH:69][cH:70]2)[cH:71][cH:72][cH:73][cH:74][cH:75]1>>[c:2]1(-[c:17]2[cH:16][cH:15][n:14][c:13]([Cl:12])[cH:18]2)[cH:3][n:4][c:5]2[n:6]1[cH:7][cH:8][c:9]([Cl:11])[cH:10]2

Participants

9

Reactant 8

HCID 923Sodium ion2×HCID 962WaterHCID 80711,2-DimethoxyethaneHCID 11776Triphenylphosphine2×HCID 19660Carbonate IonHCID 24290Palladium ChlorideHCID 51515952-Chloropyridine-4-boronic acidHCID 467391183-Bromo-7-chloroimidazo[1,2-a]pyridine

Product 1

HCID 866443437-Chloro-3-(2-chloro-pyridin-4-yl)-imidazo[1,2-a]pyridine

Sources & evidence

ORD record
ord-e67c3423751449d78554ee43f25ec9ce
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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