Dichloromethane → 2-[4-(3-Aminopyrrolidin-1-yl)-7-methylquinazolin-2-yl]phenol

HRID 1125264Notes

Reaction equation

HRID 1125264 reaction equation
[Cl:39][CH2:40][Cl:41].[OH:1][c:2]1[c:3](-[c:8]2[n:9][c:10]3[cH:11][c:12]([CH3:31])[cH:13][cH:14][c:15]3[c:16]([N:18]3[CH2:19][CH:20]([NH:23][C:24](=[O:25])[O:26][C:27]([CH3:28])([CH3:29])[CH3:30])[CH2:21][CH2:22]3)[n:17]2)[cH:4][cH:5][cH:6][cH:7]1.[OH:32][C:33]([C:34]([F:35])([F:36])[F:37])=[O:38]>>[OH:1][c:2]1[c:3](-[c:8]2[n:9][c:10]3[cH:11][c:12]([CH3:31])[cH:13][cH:14][c:15]3[c:16]([N:18]3[CH2:19][CH:20]([NH2:23])[CH2:21][CH2:22]3)[n:17]2)[cH:4][cH:5][cH:6][cH:7]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 136121483tert-butyl N-[1-[2-(2-hydroxyphenyl)-7-methylquinazolin-4-yl]pyrrolidin-3-yl]carbamate

Product 1

HCID 1361215132-[4-(3-Aminopyrrolidin-1-yl)-7-methylquinazolin-2-yl]phenol

Sources & evidence

ORD record
ord-a3e67fb4d1344946bbeaa5fcf97c5c05
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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