Trifluoroacetic acid → N-(3-Fluoro-4-(2-(4-oxocyclohexyl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-2-(4-fluorophenyl)-3-oxo-2,3-dihydropyridazine-4-carboxamide

HRID 1125336Notes

Reaction equation

HRID 1125336 reaction equation
[F:45][C:46]([F:47])([F:48])[C:49]([OH:50])=[O:51].[O:1]1[CH2:3][CH2:2][O:4][C:5]12[CH2:6][CH2:7][CH:8]([c:11]1[cH:12][c:13]3[n:14][cH:15][cH:16][c:17]([O:20][c:21]4[c:22]([F:44])[cH:23][c:24]([NH:27][C:28](=[O:29])[c:30]5[c:31](=[O:43])[n:32](-[c:36]6[cH:37][cH:38][c:39]([F:42])[cH:40][cH:41]6)[n:33][cH:34][cH:35]5)[cH:25][cH:26]4)[c:18]3[s:19]1)[CH2:9][CH2:10]2>>[O:4]=[C:5]1[CH2:6][CH2:7][CH:8]([c:11]2[cH:12][c:13]3[n:14][cH:15][cH:16][c:17]([O:20][c:21]4[c:22]([F:44])[cH:23][c:24]([NH:27][C:28](=[O:29])[c:30]5[c:31](=[O:43])[n:32](-[c:36]6[cH:37][cH:38][c:39]([F:42])[cH:40][cH:41]6)[n:33][cH:34][cH:35]5)[cH:25][cH:26]4)[c:18]3[s:19]2)[CH2:9][CH2:10]1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 67347914N-(4-(2-(1,4-dioxaspiro[4.5]decan-8-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-2-(4-fluorophenyl)-3-oxo-2,3-dihydropyridazine-4-carboxamide

Product 1

HCID 58949495N-(3-Fluoro-4-(2-(4-oxocyclohexyl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-2-(4-fluorophenyl)-3-oxo-2,3-dihydropyridazine-4-carboxamide

Sources & evidence

ORD record
ord-2f227f9f4895450a97c7b6bc6339e996
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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