Tetrahydrofuran → 1-(2-ethyl-4-(2,2,2-trifluoroethylthio)cyclopentyl)-6-((2-(trimethylsilyl)ethoxy)methyl)-6H-pyrrolo[2,3-e][1,2,4]triazolo[4,3-a]pyrazine

HRID 1125571Notes

Reaction equation

HRID 1125571 reaction equation
[CH2:15]([CH3:16])[CH:17]1[CH2:18][CH:19]([OH:42])[CH2:20][CH:21]1[c:22]1[n:23][n:24][c:25]2[n:26]1[c:27]1[c:28]([n:29][cH:30]2)[n:31]([CH2:34][O:35][CH2:36][CH2:37][Si:38]([CH3:39])([CH3:40])[CH3:41])[cH:32][cH:33]1.[CH2:49]1[O:50][CH2:51][CH2:52][CH2:53]1.[F:43][C:44]([CH2:45][SH:46])([F:47])[F:48].[O:1]=[C:2]([O:3][CH:4]([CH3:5])[CH3:6])[N:7]=[N:8][C:9]([O:10][CH:11]([CH3:12])[CH3:13])=[O:14]>>[CH2:15]([CH3:16])[CH:17]1[CH2:18][CH:19]([S:46][CH2:45][C:44]([F:43])([F:47])[F:48])[CH2:20][CH:21]1[c:22]1[n:23][n:24][c:25]2[n:26]1[c:27]1[c:28]([n:29][cH:30]2)[n:31]([CH2:34][O:35][CH2:36][CH2:37][Si:38]([CH3:39])([CH3:40])[CH3:41])[cH:32][cH:33]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 75555Diisopropyl diazene-1,2-dicarboxylateHCID 41339242,2,2-TrifluoroethanethiolHCID 585572033-ethyl-4-(6-((2-(trimethylsilyl)ethoxy)methyl)-6H-pyrrolo[2,3-e][1,2,4]triazolo[4,3-a]pyrazin-1-yl)cyclopentanol

Product 1

HCID 585574931-(2-ethyl-4-(2,2,2-trifluoroethylthio)cyclopentyl)-6-((2-(trimethylsilyl)ethoxy)methyl)-6H-pyrrolo[2,3-e][1,2,4]triazolo[4,3-a]pyrazine

Sources & evidence

ORD record
ord-c3bc514996d442d2b8c1dd87bc4098a1
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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