Dichloromethane → 5-chloro-N-[1-(1,3-dioxoisoindol-2-yl)-3-[2-(trifluoromethyl)phenyl]propan-2-yl]-4-(4-fluoro-1-methylpyrazol-5-yl)thiophene-2-carboxamide

HRID 1125703Notes

Reaction equation

HRID 1125703 reaction equation
[Br:58][P+:59]([N:60]1[CH2:61][CH2:62][CH2:63][CH2:64]1)([N:65]1[CH2:66][CH2:67][CH2:68][CH2:69]1)[N:70]1[CH2:71][CH2:72][CH2:73][CH2:74]1.[CH:42]([N:43]([CH:44]([CH3:45])[CH3:46])[CH2:47][CH3:48])([CH3:49])[CH3:50].[Cl:1][c:2]1[c:3](-[c:10]2[c:11]([F:16])[cH:12][n:13][n:14]2[CH3:15])[cH:4][c:5]([C:7](=[O:8])[OH:9])[s:6]1.[Cl:75][CH2:76][Cl:77].[NH2:17][CH:18]([CH2:19][N:20]1[C:21](=[O:30])[c:22]2[cH:23][cH:24][cH:25][cH:26][c:27]2[C:28]1=[O:29])[CH2:31][c:32]1[c:33]([C:38]([F:39])([F:40])[F:41])[cH:34][cH:35][cH:36][cH:37]1.[P-:51]([F:52])([F:53])([F:54])([F:55])([F:56])[F:57]>>[Cl:1][c:2]1[c:3](-[c:10]2[c:11]([F:16])[cH:12][n:13][n:14]2[CH3:15])[cH:4][c:5]([C:7](=[O:9])[NH:17][CH:18]([CH2:19][N:20]2[C:21](=[O:30])[c:22]3[cH:23][cH:24][cH:25][cH:26][c:27]3[C:28]2=[O:29])[CH2:31][c:32]2[c:33]([C:38]([F:39])([F:40])[F:41])[cH:34][cH:35][cH:36][cH:37]2)[s:6]1

Participants

7

Reactant 6

HCID 6344DichloromethaneHCID 9886HexafluorophosphateHCID 81531DiisopropylethylamineHCID 2733180Bromotripyrrolidin-1-ylphosphoniumHCID 578265875-chloro-4-(4-fluoro-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxylic acidHCID 1785107622-[2-amino-3-[2-(trifluoromethyl)phenyl]propyl]isoindole-1,3-dione

Product 1

HCID 765763255-chloro-N-[1-(1,3-dioxoisoindol-2-yl)-3-[2-(trifluoromethyl)phenyl]propan-2-yl]-4-(4-fluoro-1-methylpyrazol-5-yl)thiophene-2-carboxamide

Sources & evidence

ORD record
ord-0bf4a2b90fc94bf8a1285843d22ac352
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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