Acetonitrile → 5-Chloro-2-{4-[(imidazo[1,2-a]pyridin-7-ylmethyl)-amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl}-benzonitrile

HRID 1126343Notes

Reaction equation

HRID 1126343 reaction equation
[CH3:41][C:42]#[N:43].[CH:32]([N:33]([CH2:34][CH3:35])[CH:36]([CH3:37])[CH3:38])([CH3:39])[CH3:40].[Cl:1][c:2]1[cH:3][cH:4][c:5]([N:10]2[CH2:11][c:12]3[c:13]([n:14][cH:15][n:16][c:17]3[Cl:18])[CH2:19][CH2:20]2)[c:6]([C:7]#[N:8])[cH:9]1.[n:21]1[cH:22][cH:23][n:24]2[c:25]1[cH:26][c:27]([CH2:30][NH2:31])[cH:28][cH:29]2>>[Cl:1][c:2]1[cH:3][cH:4][c:5]([N:10]2[CH2:11][c:12]3[c:13]([n:14][cH:15][n:16][c:17]3[NH:31][CH2:30][c:27]3[cH:26][c:25]4[n:21][cH:22][cH:23][n:24]4[cH:29][cH:28]3)[CH2:19][CH2:20]2)[c:6]([C:7]#[N:8])[cH:9]1

Participants

5

Reactant 4

HCID 6342AcetonitrileHCID 81531DiisopropylethylamineHCID 55289825Imidazo(1,2-a)pyridin-7-ylmethanamineHCID 598406875-Chloro-2-(4-chloro-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)benzonitrile

Product 1

HCID 250595425-Chloro-2-{4-[(imidazo[1,2-a]pyridin-7-ylmethyl)-amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl}-benzonitrile

Sources & evidence

ORD record
ord-7a9dcc3b66dd423582382a3a42bf744b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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