反应详情

In 86 ml of ethanol and 86 ml of tetrahydrofuran 2.56 g (6.68 mmol) of the compound from example 41A are stirred in the presence of 288 mg of Pd/C (10%) under an H2 atmosphere for 20 hours. The reaction solution is filtered with suction through 30 ml of silica gel, the filter cake is washed with ethanol/tetrahydrofuran and the filtrate is concentrated and dried under high vacuum overnight. The crude product is chromatographed on 500 ml of silica gel using toluene and ethyl acetate in a gradient system.

1. filtrationThe reaction solution is filtered with suction through 30 ml of silica gel
2. washthe filter cake is washed with ethanol/tetrahydrofuran
3. concentrationthe filtrate is concentrated
4. customdried under high vacuum overnight
5. customThe crude product is chromatographed on 500 ml of silica gel