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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1127191Generated: October 25, 2026

Dichloromethane → (3S,4R)-Methyl 1-(tert-butyl)-4-(2,4-difluorophenyl)pyrrolidine-3-carboxylate

https://huagongshe.com/reaction/1127191

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDichloromethaneHCID 6344—
ReactantTrifluoroacetic acidHCID 6422—
Reactant4-ChloropyrimidineHCID 642834—
ReactantN-tert-Butyl-N-(methoxymethyl)-N-(trimethylsilylmethyl)amineHCID 22228418—
ReactantMethyl 3-(2,4-difluorophenyl)prop-2-enoateHCID 53433282—
Product(3S,4R)-Methyl 1-(tert-butyl)-4-(2,4-difluorophenyl)pyrrolidine-3-carboxylateHCID 23525689—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetTraining data from https://doi.org/10.1039/C8SC04228D (7/10)
ORD IDord-bc8487729f624cb380095815a86e57fa
Source noteTraining data from https://doi.org/10.1039/C8SC04228D (7/10)