HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → 2-[5-(3-Cyanobenzenesulfonamido)-2-propoxyphenyl]-5-methyl-7-cyclopentyl-3H-imidazo[5,1-f][1,2,4]-triazin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | 3-Cyanobenzene-1-sulfonyl chloride | HCID 2801360 | — |
| Reactant | 2-(5-Amino-2-propoxyphenyl)-5-methyl-7-cyclopentyl-3H-imidazo[5,1-f][1,2,4]-triazin-4-one | HCID 135604925 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-[5-(3-Cyanobenzenesulfonamido)-2-propoxyphenyl]-5-methyl-7-cyclopentyl-3H-imidazo[5,1-f][1,2,4]-triazin-4-one | HCID 135604958 | — |
Reaction Steps
200 mg (0.566 mmol) of the compound from example 44A are reaccted with 342 mg (1.70 mmol) of 3-cyanobenzenesulfonyl chloride and 0.46 ml (5.66 mmol) of pyridine in 15 ml of tetrahydrofuran overnight.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07098207B2 |
| Source dataset | uspto-grants-2006_08 |
| ORD ID | ord-3f190f042da046bd91a26572743fe5ea |
| Source note | uspto-grants-2006_08 |