Trifluoroacetic acid → HCID 135604946, compound

HRID 11280Notes

Reaction equation

HRID 11280 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10][CH:9]1[C:21]([NH:23][C:24]1[CH:25]=[CH:26][C:27]([O:46][CH2:47][CH3:48])=[C:28]([C:30]2[NH:35][C:34](=[O:36])[C:33]3=[C:37]([CH3:45])[N:38]=[C:39]([CH:40]4[CH2:44][CH2:43][CH2:42][CH2:41]4)[N:32]3[N:31]=2)[CH:29]=1)=[O:22])=O)(C)(C)C.FC(F)(F)C(O)=O>>[CH2:47]([O:46][C:27]1[CH:26]=[CH:25][C:24]([NH:23][C:21]([CH:9]2[CH2:10][NH:11][CH2:12][CH2:13][NH:8]2)=[O:22])=[CH:29][C:28]=1[C:30]1[NH:35][C:34](=[O:36])[C:33]2=[C:37]([CH3:45])[N:38]=[C:39]([CH:40]3[CH2:44][CH2:43][CH2:42][CH2:41]3)[N:32]2[N:31]=1)[CH3:48]

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 135698333HCID 135698333, compound

Product 1

HCID 135604946HCID 135604946, compound

Procedure

132 mg (0.198 mmol) of the compound from example 48 are treated with 5 ml of trifluoroacetic acid for 90 minutes; the solution is then concentrated, dichloromethane and 10% strength NaHCO3 solution are added to the residue and the organic phase is dried and concentrated under reduced pressure.

Workup

  1. concentrationthe solution is then concentrated
  2. additiondichloromethane and 10% strength NaHCO3 solution are added to the residue
  3. customthe organic phase is dried
  4. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-dad14497ec5c4cf081a9bff140e7ecfa
Source dataset
uspto-grants-2006_08
Patent number
US07098207B2

Reaction notes

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