Ethanol → N-[5-(2-amino-1-hydroxyethyl)-2-(2-trimethylsilylethoxymethoxy)phenyl]formamide

HRID 1128157Notes

Reaction equation

HRID 1128157 reaction equation
[CH3:39][CH2:40][O:41][C:42]([CH3:43])=[O:44].[CH3:45][CH2:46][OH:47].[H:37][H:38].[OH-:48].[OH-:50].[Pd+2:49].[c:1]1([CH2:2][N:8]([CH2:3][c:4]2[cH:5][cH:6][cH:7][cH:30][cH:31]2)[CH2:9][CH:10]([OH:11])[c:12]2[cH:13][cH:14][c:15]([O:21][CH2:22][O:23][CH2:24][CH2:25][Si:26]([CH3:27])([CH3:28])[CH3:29])[c:16]([NH:18][CH:19]=[O:20])[cH:17]2)[cH:32][cH:33][cH:34][cH:35][cH:36]1>>[NH2:8][CH2:9][CH:10]([OH:11])[c:12]1[cH:13][cH:14][c:15]([O:21][CH2:22][O:23][CH2:24][CH2:25][Si:26]([CH3:27])([CH3:28])[CH3:29])[c:16]([NH:18][CH:19]=[O:20])[cH:17]1

Participants

7

Reactant 6

HCID 702EthanolHCID 961Hydroxide2×HCID 8857Ethyl AcetateHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 91031622N-[5-[2-(dibenzylamino)-1-hydroxyethyl]-2-(2-trimethylsilylethoxymethoxy)phenyl]formamideHCID 178418361HCID 178418361, compound

Product 1

HCID 91516522N-[5-(2-amino-1-hydroxyethyl)-2-(2-trimethylsilylethoxymethoxy)phenyl]formamide

Sources & evidence

ORD record
ord-48ff14e914374516bb7c64cbaeba1386
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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