Hydrochloric Acid → N-(3-(3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-5-chloropicolinamide

HRID 1128266Notes

Reaction equation

HRID 1128266 reaction equation
[Cl:1][c:2]1[cH:3][cH:4][c:5]([C:8](=[O:9])[NH:10][c:11]2[cH:12][cH:13][c:14]([F:35])[c:15]([C:17]3([CH3:34])[N:18]=[C:19]([NH:26][C:27](=[O:28])[O:29][C:30]([CH3:31])([CH3:32])[CH3:33])[CH2:20][O:21][CH2:22][C:23]3([F:24])[F:25])[cH:16]2)[n:6][cH:7]1.[ClH:42].[O:36]1[CH2:37][CH2:38][O:39][CH2:40][CH2:41]1>>[Cl:1][c:2]1[cH:3][cH:4][c:5]([C:8](=[O:9])[NH:10][c:11]2[cH:12][cH:13][c:14]([F:35])[c:15]([C:17]3([CH3:34])[N:18]=[C:19]([NH2:26])[CH2:20][O:21][CH2:22][C:23]3([F:24])[F:25])[cH:16]2)[n:6][cH:7]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 66666053Tert-butyl 5-(5-(5-chloropicolinamido)-2-fluorophenyl)-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-3-ylcarbamate

Product 1

HCID 50913364N-(3-(3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-5-chloropicolinamide

Sources & evidence

ORD record
ord-3723625066db40e195e5e10102c3d934
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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