1-Butanol → 1-Benzyl-4-cyano-4-phenylpiperidine

HRID 1128349Notes

Reaction equation

HRID 1128349 reaction equation
[Br:15][CH2:16][c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1.[CH2:29]([OH:30])[CH2:31][CH2:32][CH3:33].[Na+:23].[Na+:24].[O-:25][C:26](=[O:27])[O-:28].[c:1]1([C:7]2([C:13]#[N:14])[CH2:8][CH2:9][NH:10][CH2:11][CH2:12]2)[cH:2][cH:3][cH:4][cH:5][cH:6]1>>[c:1]1([C:7]2([C:13]#[N:14])[CH2:8][CH2:9][N:10]([CH2:16][c:17]3[cH:18][cH:19][cH:20][cH:21][cH:22]3)[CH2:11][CH2:12]2)[cH:2][cH:3][cH:4][cH:5][cH:6]1

Participants

6

Reactant 5

HCID 2631-ButanolHCID 923Sodium ion2×HCID 7498Benzyl BromideHCID 19660Carbonate IonHCID 1811384-Piperidinecarbonitrile, 4-phenyl-

Product 1

HCID 1914081-Benzyl-4-cyano-4-phenylpiperidine

Sources & evidence

ORD record
ord-9b34090a368d44528968c67c232a24c7
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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