Acetate → Methyl 3-amino-6-methylpyrazine-2-carboxylate

HRID 1128814Notes

Reaction equation

HRID 1128814 reaction equation
[C:33]([O-:34])(=[O:35])[CH3:36].[C:38]([O-:39])(=[O:40])[CH3:41].[CH3:13][c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1.[CH3:1][O:2][C:3](=[O:4])[c:5]1[n:6][c:7]([Br:12])[cH:8][n:9][c:10]1[NH2:11].[CH3:20][B:21]([OH:22])[OH:23].[ClH:32].[K+:29].[K+:30].[K+:31].[OH2:42].[P:24]([O-:25])([O-:26])([O-:27])=[O:28].[Pd+2:37]>>[CH3:1][O:2][C:3](=[O:4])[c:5]1[n:6][c:7]([CH3:13])[cH:8][n:9][c:10]1[NH2:11]

Participants

10

Reactant 9

HCID 175Acetate2×HCID 313Hydrochloric AcidHCID 813Potassium Cation3×HCID 962WaterHCID 1061PhosphateHCID 1140TolueneHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 139377Methylboronic AcidHCID 227251Methyl 3-Amino-6-bromopyrazine-2-carboxylate

Product 1

HCID 58840780Methyl 3-amino-6-methylpyrazine-2-carboxylate

Sources & evidence

ORD record
ord-a70feab93ebd4b05a43a6674c6aeb65e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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