HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Ethoxypiperidine → 1-Cyclopropyl-6-fluoro-1,4-dihydro-5-methyl-7-(4'-ethoxypiperidin-1-yl)-4-oxo-quinoline-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Ethoxypiperidine | HCID 11506519 | — |
| Reactant | 1-Cyclopropyl-6,7-difluoro-5-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid | HCID 14651254 | — |
| Product | 1-Cyclopropyl-6-fluoro-1,4-dihydro-5-methyl-7-(4'-ethoxypiperidin-1-yl)-4-oxo-quinoline-3-carboxylic acid | HCID 10178348 | 40% |
Reaction Steps
The condensation of 1-cyclopropyl-6,7-difluoro-5-methyl-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid with 4-ethoxypiperidine in a similar manner as described in example 1 give the titled product. Yield 40%, m.p 180–82° C., C21H21FN2O4, m/z 388 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07098219B2 |
| Source dataset | uspto-grants-2006_08 |
| ORD ID | ord-27c06f800c23468692cd6929498a301c |
| Source note | uspto-grants-2006_08 |