2,2,2-Trifluoroethanol → 6-(4-Chloro-phenyl)-5-(2,2,2-trifluoro-ethoxy)-pyrazine-2-carboxylic acid methyl ester

HRID 1129673Notes

Reaction equation

HRID 1129673 reaction equation
[CH3:1][O:2][C:3](=[O:4])[c:5]1[n:6][c:7](-[c:12]2[cH:13][cH:14][c:15]([Cl:18])[cH:16][cH:17]2)[c:8]([Br:11])[n:9][cH:10]1.[OH:19][CH2:20][C:21]([F:22])([F:23])[F:24]>>[CH3:1][O:2][C:3](=[O:4])[c:5]1[n:6][c:7](-[c:12]2[cH:13][cH:14][c:15]([Cl:18])[cH:16][cH:17]2)[c:8]([O:19][CH2:20][C:21]([F:22])([F:23])[F:24])[n:9][cH:10]1

Participants

3

Reactant 2

HCID 64092,2,2-TrifluoroethanolHCID 86619571Methyl 5-bromo-6-(4-chlorophenyl)pyrazine-2-carboxylate

Product 1

HCID 672810366-(4-Chloro-phenyl)-5-(2,2,2-trifluoro-ethoxy)-pyrazine-2-carboxylic acid methyl ester

Sources & evidence

ORD record
ord-56c3aa9e829d4229b06221ff851a5bb1
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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