Dichloromethane → 2,2,2-trichloro-1-[10-(2'-methoxy-2-methyl-biphenyl-4-carbonyl)-10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-3-yl]-ethanone

HRID 1129987Notes

Reaction equation

HRID 1129987 reaction equation
[CH:32]([N:33]([CH2:34][CH3:35])[CH:36]([CH3:37])[CH3:38])([CH3:39])[CH3:40].[Cl:41][C:42]([C:43](=[O:44])[Cl:45])([Cl:46])[Cl:47].[Cl:48][CH2:49][Cl:50].[cH:1]1[cH:2][cH:3][n:4]2[c:5]1[CH2:6][N:7]([C:15](=[O:16])[c:17]1[cH:18][c:19]([CH3:31])[c:20](-[c:23]3[c:24]([O:29][CH3:30])[cH:25][cH:26][cH:27][cH:28]3)[cH:21][cH:22]1)[c:8]1[c:9]([cH:11][cH:12][cH:13][cH:14]1)[CH2:10]2>>[cH:1]1[cH:2][c:3]([C:43]([C:42]([Cl:41])([Cl:46])[Cl:47])=[O:44])[n:4]2[c:5]1[CH2:6][N:7]([C:15](=[O:16])[c:17]1[cH:18][c:19]([CH3:31])[c:20](-[c:23]3[c:24]([O:29][CH3:30])[cH:25][cH:26][cH:27][cH:28]3)[cH:21][cH:22]1)[c:8]1[c:9]([cH:11][cH:12][cH:13][cH:14]1)[CH2:10]2

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 6420Trichloroacetyl chlorideHCID 81531DiisopropylethylamineHCID 21947842(10,11-Dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-10-yl)-(2'-methoxy-2-methyl-[1,1'-biphenyl]-4-yl)-methanone

Product 1

HCID 219479472,2,2-trichloro-1-[10-(2'-methoxy-2-methyl-biphenyl-4-carbonyl)-10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-3-yl]-ethanone

Sources & evidence

ORD record
ord-cd7feeb02feb44b9ba5a1a70f22ea66d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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