Dichloromethane → Trifluoroacetic acid

HRID 1130055Notes

Reaction equation

HRID 1130055 reaction equation
[Cl:40][CH2:41][Cl:42].[F:33][C:34]([C:35](=[O:36])[OH:37])([F:38])[F:39].[c:1]1([CH:7]([N:8]2[CH2:9][CH:10]([N:12]3[CH:13]([CH2:25][OH:26])[CH2:14][N:15]([C:18]([O:19][C:20]([CH3:21])([CH3:22])[CH3:23])=[O:24])[CH2:16][CH2:17]3)[CH2:11]2)[c:27]2[cH:28][cH:29][cH:30][cH:31][cH:32]2)[cH:2][cH:3][cH:4][cH:5][cH:6]1>>[F:33][C:34]([C:35](=[O:36])[OH:37])([F:38])[F:39].[c:1]1([CH:7]([N:8]2[CH2:9][CH:10]([N:12]3[CH:13]([CH2:25][OH:26])[CH2:14][NH:15][CH2:16][CH2:17]3)[CH2:11]2)[c:27]2[cH:28][cH:29][cH:30][cH:31][cH:32]2)[cH:2][cH:3][cH:4][cH:5][cH:6]1

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 59625963Tert-butyl 4-(1-benzhydrylazetidin-3-yl)-3-(hydroxymethyl)piperazine-1-carboxylate

Product 2

HCID 6422Trifluoroacetic acidHCID 59625873{1-[1-(Diphenylmethyl)azetidin-3-yl]-piperazin-2-yl}methanol

Sources & evidence

ORD record
ord-b1772e65d81e4d43bddf544297a05038
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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