HCID 10125063, compound → 5-Amino-1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(4-methylamino-3,3-dimethyl-1-piperidinyl)-4-oxo-quinoline-3-carboxylic Acid

HRID 11302Notes

Reaction equation

HRID 11302 reaction equation
[NH2:1][C:2]1[C:11]([F:12])=[C:10](F)[C:9]([O:14][CH3:15])=[C:8]2[C:3]=1[C:4](=[O:22])[C:5]([C:19]([OH:21])=[O:20])=[CH:6][N:7]2[CH:16]1[CH2:18][CH2:17]1.[CH3:23][NH:24][CH:25]1[CH2:30][CH2:29][NH:28][CH2:27][C:26]1([CH3:32])[CH3:31]>>[NH2:1][C:2]1[C:11]([F:12])=[C:10]([N:28]2[CH2:29][CH2:30][CH:25]([NH:24][CH3:23])[C:26]([CH3:32])([CH3:31])[CH2:27]2)[C:9]([O:14][CH3:15])=[C:8]2[C:3]=1[C:4](=[O:22])[C:5]([C:19]([OH:21])=[O:20])=[CH:6][N:7]2[CH:16]1[CH2:18][CH2:17]1

Participants

3

Reactant 2

HCID 10125063HCID 10125063, compoundHCID 105668945-Amino-1-cyclopropyl-6,7-difluoro-8-methoxy-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

Product 1

HCID 101376665-Amino-1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(4-methylamino-3,3-dimethyl-1-piperidinyl)-4-oxo-quinoline-3-carboxylic AcidYield 54%

Procedure

The condensation of 5-amino-1-cyclopropyl-6,7-difluoro-8-methoxy-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid with 4-methylamino-3,3-dimethylpiperidine was carried out in a similar manner as described in example 1 (NorA), gave the titled product. Yield 54%, m.p 250° C., C22H29FN4O4, m/z 433 (M+1).

Sources & evidence

ORD record
ord-9e02f934b01a4fad9459c6326aaa2d90
Source dataset
uspto-grants-2006_08
Patent number
US07098219B2

Reaction notes

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