Hydrochloric Acid → 3-Piperidin-4-yl-7-trifluoromethyl-benzo[d]isoxazole

HRID 1130305Notes

Reaction equation

HRID 1130305 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH2:10][CH:11]([c:14]2[n:15][o:16][c:17]3[c:18]2[cH:19][cH:20][cH:21][c:22]3[C:23]([F:24])([F:25])[F:26])[CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:7].[CH3:28][OH:29].[ClH:27]>>[NH:8]1[CH2:9][CH2:10][CH:11]([c:14]2[n:15][o:16][c:17]3[c:18]2[cH:19][cH:20][cH:21][c:22]3[C:23]([F:24])([F:25])[F:26])[CH2:12][CH2:13]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 588176024-(7-Trifluoromethyl-benzo[d]isoxazol-3-yl)-piperidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 231124413-Piperidin-4-yl-7-trifluoromethyl-benzo[d]isoxazole

Sources & evidence

ORD record
ord-c6b2b16c67c34441854e9164d33b2222
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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