Trifluoroacetic acid → 6-chloro4'-(3-chlorophenyl)-2'-(2,3-difluoro-6-isopropoxy-phenyl)-1'-(3-morpholin-4-yl-propyl)spiro[3H-indole-3,3'-piperidine]-2,6'(1H)-dione

HRID 1130453Notes

Reaction equation

[CH2:49]1[CH2:50][O:51][CH2:52][CH2:53][NH:54]1.[CH3:1][O:2][CH:3]([Si:4]([CH3:5])([CH3:6])[CH3:7])[CH3:8].[Cl:9][c:10]1[cH:11][cH:12][c:13]2[c:17]([cH:18]1)[NH:16][C:15](=[O:19])[C:14]21[CH:20]([c:37]2[c:38]([F:48])[c:39]([F:47])[cH:40][cH:41][c:42]2[O:43][CH:44]([CH3:45])[CH3:46])[N:21]([CH2:33][CH2:34][CH2:35][Cl:36])[C:22](=[O:32])[CH2:23][CH:24]1[c:25]1[cH:26][c:27]([Cl:31])[cH:28][cH:29][cH:30]1.[OH:55][C:56]([C:57]([F:58])([F:59])[F:60])=[O:61]>>[Cl:9][c:10]1[cH:11][cH:12][c:13]2[c:17]([cH:18]1)[NH:16][C:15](=[O:19])[C:14]21[CH:20]([c:37]2[c:38]([F:48])[c:39]([F:47])[cH:40][cH:41][c:42]2[O:43][CH:44]([CH3:45])[CH3:46])[N:21]([CH2:33][CH2:34][CH2:35][N:54]2[CH2:49][CH2:50][O:51][CH2:52][CH2:53]2)[C:22](=[O:32])[CH2:23][CH:24]1[c:25]1[cH:26][c:27]([Cl:31])[cH:28][cH:29][cH:30]1

Participants

Reactant 4

HCID 6422Trifluoroacetic acid

HCID 8083Morpholine

HCID 22400412(1-Methoxyethyl)(trimethyl)silane

HCID 775806576-chloro-4'-(3-chlorophenyl)-1'-(3-chloropropyl)-6'-(2,3-difluoro-6-propan-2-yloxyphenyl)spiro[1H-indole-3,5'-piperidine]-2,2'-dione

Product 1

HCID 743705376-chloro4'-(3-chlorophenyl)-2'-(2,3-difluoro-6-isopropoxy-phenyl)-1'-(3-morpholin-4-yl-propyl)spiro[3H-indole-3,3'-piperidine]-2,6'(1H)-dione

Sources & evidence

ORD record: ord-b233ed3b650a4b79a0bd990861e86ec1
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (7/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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