Imidazole → Tert-butyl 3-[tert-butyl(dimethyl)silyl]oxy-2-cyclopropyl-5-oxopyrrolidine-1-carboxylate

HRID 1131481Notes

Reaction equation

HRID 1131481 reaction equation
[C:18]([CH3:19])([CH3:20])([CH3:21])[Si:22]([CH3:23])([CH3:24])[Cl:25].[CH:1]1([CH:4]2[N:5]([C:11](=[O:12])[O:13][C:14]([CH3:15])([CH3:16])[CH3:17])[C:6](=[O:10])[CH2:7][CH:8]2[OH:9])[CH2:2][CH2:3]1.[O:31]=[CH:32][N:33]([CH3:34])[CH3:35].[nH:26]1[cH:27][cH:28][n:29][cH:30]1>>[CH:1]1([CH:4]2[N:5]([C:11](=[O:12])[O:13][C:14]([CH3:15])([CH3:16])[CH3:17])[C:6](=[O:10])[CH2:7][CH:8]2[O:9][Si:22]([C:18]([CH3:19])([CH3:20])[CH3:21])([CH3:23])[CH3:24])[CH2:2][CH2:3]1

Participants

5

Reactant 4

HCID 795ImidazoleHCID 6228DimethylformamideHCID 28928tert-Butyldimethylsilyl chlorideHCID 67314043HCID 67314043, compound

Product 1

HCID 67313763Tert-butyl 3-[tert-butyl(dimethyl)silyl]oxy-2-cyclopropyl-5-oxopyrrolidine-1-carboxylate

Sources & evidence

ORD record
ord-1b9ad185abf447bfac43ed0541baa24f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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