Methanol → tert-Butyl 6-cyano-5-(tert-butyldiphenylsilyloxy)-3-oxohexanoate
Reaction equation
[C:12]([CH3:13])(=[O:14])[O:15][C:16]([CH3:17])([CH3:18])[CH3:19].[C:20](#[N:21])[CH2:22][CH:23]([CH2:24][C:25](=[O:26])[O:27][CH2:28][CH3:29])[O:30][Si:31]([c:32]1[cH:33][cH:34][cH:35][cH:36][cH:37]1)([c:38]1[cH:39][cH:40][cH:41][cH:42][cH:43]1)[C:44]([CH3:45])([CH3:46])[CH3:47].[CH2:1]([Li:2])[CH2:3][CH2:4][CH3:5].[CH2:48]1[O:49][CH2:50][CH2:51][CH2:52]1.[CH3:54][OH:55].[CH3:6][CH2:7][CH2:8][CH2:9][CH2:10][CH3:11].[OH2:53]>>[C:12]([CH2:13][C:25]([CH2:24][CH:23]([CH2:22][C:20]#[N:21])[O:30][Si:31]([c:32]1[cH:33][cH:34][cH:35][cH:36][cH:37]1)([c:38]1[cH:39][cH:40][cH:41][cH:42][cH:43]1)[C:44]([CH3:45])([CH3:46])[CH3:47])=[O:26])(=[O:14])[O:15][C:16]([CH3:17])([CH3:18])[CH3:19]Participants
8
Sources & evidence
- ORD record
- ord-0963d6ffa1f042aa8d5ec8ea88d8ecd2
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (7/10)
Reaction notes
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