Sodium ion → 4-[4-(4-Fluorophenyl)-1-piperidin-4-yl-1H-imidazol-5-yl]pyrimidine

HRID 1131900Notes

Reaction equation

HRID 1131900 reaction equation
[Cl:41][CH2:42][Cl:43].[F:1][C:2]([F:3])([F:4])[C:5]([OH:6])=[O:7].[F:8][c:9]1[cH:10][cH:11][c:12](-[c:15]2[n:16][cH:17][n:18]([CH:26]3[CH2:27][CH2:28][N:29]([C:32]([O:33][C:34]([CH3:35])([CH3:36])[CH3:37])=[O:38])[CH2:30][CH2:31]3)[c:19]2-[c:20]2[n:21][cH:22][n:23][cH:24][cH:25]2)[cH:13][cH:14]1.[Na+:40].[OH-:39]>>[F:8][c:9]1[cH:10][cH:11][c:12](-[c:15]2[n:16][cH:17][n:18]([CH:26]3[CH2:27][CH2:28][NH:29][CH2:30][CH2:31]3)[c:19]2-[c:20]2[n:21][cH:22][n:23][cH:24][cH:25]2)[cH:13][cH:14]1

Participants

6

Reactant 5

HCID 923Sodium ionHCID 961HydroxideHCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 58235130tert-butyl 4-[4-(4-fluorophenyl)-5-pyrimidin-4-yl-1H-imidazol-1-yl]piperidine-1-carboxylate

Product 1

HCID 574617184-[4-(4-Fluorophenyl)-1-piperidin-4-yl-1H-imidazol-5-yl]pyrimidine

Sources & evidence

ORD record
ord-d88f49c0790a4df48c2be3653dac84be
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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