Methanol → 6-chloro-4'-[5-chloro-2-(1-hydroxycarbonyl-1-propyl-butoxy)-phenyl]-2'-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3'-piperidine]-2,6'(1H)-dione
Reaction equation
[CH3:50][OH:51].[Cl:1][c:2]1[cH:3][cH:4][c:5]2[c:9]([cH:10]1)[NH:8][C:7](=[O:11])[C:6]21[CH:12]([c:38]2[c:39]([CH3:45])[cH:40][cH:41][c:42]([F:44])[cH:43]2)[NH:13][C:14](=[O:37])[CH2:15][CH:16]1[c:17]1[c:18]([O:24][C:25]([CH2:26][CH2:27][CH3:28])([CH2:29][CH2:30][CH3:31])[C:32](=[O:33])[O:34][CH2:35][CH3:36])[cH:19][cH:20][c:21]([Cl:23])[cH:22]1.[Li+:47].[OH-:46].[OH2:48].[OH2:49]>>[Cl:1][c:2]1[cH:3][cH:4][c:5]2[c:9]([cH:10]1)[NH:8][C:7](=[O:11])[C:6]21[CH:12]([c:38]2[c:39]([CH3:45])[cH:40][cH:41][c:42]([F:44])[cH:43]2)[NH:13][C:14](=[O:37])[CH2:15][CH:16]1[c:17]1[c:18]([O:24][C:25]([CH2:26][CH2:27][CH3:28])([CH2:29][CH2:30][CH3:31])[C:32](=[O:33])[OH:34])[cH:19][cH:20][c:21]([Cl:23])[cH:22]1Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-d47253088dbd4ff6b172703085543d88
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (7/10)
Reaction notes
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