HRID1133

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11380407

Methyl 4-iodosalicylate

C8H7IO3

结构：OB(O)c1ccc2cc(OCc3ccccc3)c(C34CC5CC(CC(C5)C3)C4)cc2c1

HCID22000313

Boronic acid, [6-(phenylmethoxy)-7-tricyclo[3.3.1.13,7]dec-1-yl-2-naphthalenyl]-

C27H29BO3

PRODUCTS

生成物

结构：COC(=O)c1ccc(-c2ccc3cc(OCc4ccccc4)c(C45CC6CC(CC(C6)C4)C5)cc3c2)cc1O

HCID22000341

未命名化合物

收率 36.2%

PROCEDURE

实验过程

Following the basic procedure of Example 7(f), by reacting 5.52 g (13.4 mmol) of 7-(1-adamantyl)-6-benzyloxy-2-naphthylboronic acid with 2.46 g (8.8 mmol) of methyl 2-hydroxy-4-iodobenzoate, 1.65 g (36%) of the expected compound was obtained.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-0bc171163cc04932b98554480b9c571f
来源数据集: uspto-grants-1998_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05723499
来源说明: uspto-grants-1998_03

反应 SMILES

[C:1]12([C:11]3[CH:20]=[C:19]4[C:14]([CH:15]=[CH:16][C:17](B(O)O)=[CH:18]4)=[CH:13][C:12]=3[O:24][CH2:25][C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.[OH:32][C:33]1[CH:42]=[C:41](I)[CH:40]=[CH:39][C:34]=1[C:35]([O:37][CH3:38])=[O:36]>>[OH:32][C:33]1[CH:42]=[C:41]([C:17]2[CH:16]=[CH:15][C:14]3[C:19](=[CH:20][C:11]([C:1]45[CH2:2][CH:3]6[CH2:9][CH:7]([CH2:6][CH:5]([CH2:4]6)[CH2:10]4)[CH2:8]5)=[C:12]([O:24][CH2:25][C:26]4[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=4)[CH:13]=3)[CH:18]=2)[CH:40]=[CH:39][C:34]=1[C:35]([O:37][CH3:38])=[O:36]