Chloroform → 4-(4-chloro-1-methylpyrazol-5-yl)-N-[1-(1,3-dioxoisoindol-2-yl)-3-(4-fluorophenyl)propan-2-yl]-5-methoxythiophene-2-carboxamide

HRID 1133063Notes

Reaction equation

HRID 1133063 reaction equation
[CH3:40][C:41]([O:42][C:43]([NH:44][CH:45]([C:46]([OH:47])=[O:48])[CH2:49][c:50]1[cH:51][cH:52][cH:53][cH:54][c:55]1[C:56]([F:57])([F:58])[F:59])=[O:60])([CH3:61])[CH3:62].[CH:63]([N:64]([CH2:65][CH3:66])[CH:67]([CH3:68])[CH3:69])([CH3:70])[CH3:71].[CH:72]([Cl:73])([Cl:74])[Cl:75].[Cl:1][c:2]1[cH:3][n:4][n:5]([CH3:17])[c:6]1-[c:7]1[cH:8][c:9]([C:14](=[O:15])[OH:16])[s:10][c:11]1[O:12][CH3:13].[NH2:18][CH:19]([CH2:20][N:21]1[C:22](=[O:31])[c:23]2[cH:24][cH:25][cH:26][cH:27][c:28]2[C:29]1=[O:30])[CH2:32][c:33]1[cH:34][cH:35][c:36]([F:39])[cH:37][cH:38]1>>[Cl:1][c:2]1[cH:3][n:4][n:5]([CH3:17])[c:6]1-[c:7]1[cH:8][c:9]([C:14](=[O:16])[NH:18][CH:19]([CH2:20][N:21]2[C:22](=[O:31])[c:23]3[cH:24][cH:25][cH:26][cH:27][c:28]3[C:29]2=[O:30])[CH2:32][c:33]2[cH:34][cH:35][c:36]([F:39])[cH:37][cH:38]2)[s:10][c:11]1[O:12][CH3:13]

Participants

6

Reactant 5

HCID 6212ChloroformHCID 81531DiisopropylethylamineHCID 44446362-[(2-methylpropan-2-yl)oxycarbonylamino]-3-[2-(trifluoromethyl)phenyl]propanoic AcidHCID 578263844-(4-chloro-1-methyl-1H-pyrazol-5-yl)-5-(methyloxy)-2-thiophenecarboxylic AcidHCID 178510818HCID 178510818, compound

Product 1

HCID 1784944364-(4-chloro-1-methylpyrazol-5-yl)-N-[1-(1,3-dioxoisoindol-2-yl)-3-(4-fluorophenyl)propan-2-yl]-5-methoxythiophene-2-carboxamide

Sources & evidence

ORD record
ord-387c1577ac75453e9b7af3f98d1977ef
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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