Ammonium → 1-(2-(7-methoxyquinolin-4-yloxy)ethyl)-5-(2-oxopyrrolidin-1-yl)pyridin-2(1H)-one

HRID 1133196Notes

Reaction equation

HRID 1133196 reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5](=[O:23])[n:6]([CH2:8][CH2:9][O:10][c:11]2[cH:12][cH:13][n:14][c:15]3[cH:16][c:17]([O:21][CH3:22])[cH:18][cH:19][c:20]23)[cH:7]1.[C:36](=[O:37])([O-:38])[O-:39].[CH3:24][NH:25][CH2:26][CH2:27][NH:28][CH3:29].[CH3:46][c:47]1[cH:48][cH:49][cH:50][cH:51][cH:52]1.[Cs+:40].[Cs+:41].[Cu:44][I:45].[NH4+:43].[NH:30]1[C:31](=[O:35])[CH2:32][CH2:33][CH2:34]1.[OH-:42]>>[c:2]1([N:30]2[C:31](=[O:35])[CH2:32][CH2:33][CH2:34]2)[cH:3][cH:4][c:5](=[O:23])[n:6]([CH2:8][CH2:9][O:10][c:11]2[cH:12][cH:13][n:14][c:15]3[cH:16][c:17]([O:21][CH3:22])[cH:18][cH:19][c:20]23)[cH:7]1

Participants

10

Reactant 9

HCID 223AmmoniumHCID 961HydroxideHCID 1140TolueneHCID 8070N,N'-DimethylethylenediamineHCID 120252-PyrrolidoneHCID 19660Carbonate IonHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 104967Cesium cation2×HCID 248844955-Bromo-1-(2-(7-methoxyquinolin-4-yloxy)ethyl)pyridin-2(1H)-one

Product 1

HCID 250191681-(2-(7-methoxyquinolin-4-yloxy)ethyl)-5-(2-oxopyrrolidin-1-yl)pyridin-2(1H)-one

Sources & evidence

ORD record
ord-ce7eb1a823a34e269d4b054d040f626f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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