Ammonia → (R)-1-(4-(6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinolin-2-yl)phenyl)pyridin-4(1H)-one

Participants

Role	Name	HCID	Charge
Reactant	Ammonia	HCID 222	—
Reactant	1-[4-Methyl-2-(2-thienyl)-1,3-thiazol-5-yl]-1-ethanone	HCID 2744245	—
Reactant	1-(4-acetylphenyl)-4(1H)-pyridinone	HCID 3815063	—
Product	(R)-1-(4-(6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinolin-2-yl)phenyl)pyridin-4(1H)-one	HCID 11531634	—

Reaction Steps

The title compound was prepared using the procedure described in Example 1G using 1-(4-acetyl-phenyl)-1H-pyridin-4-one for 1-(4-methyl-2-thiophen-2-yl-thiazol-5-yl)-ethanone. 1H NMR (300 MHz, CDCl3) δ 1.15 (d, J=6.10 Hz, 3H), 1.49 (m, 1H), 1.78 (m, 2H), 1.95 (m, 1H), 2.27 (m, 1H), 2.43 (m, 2H), 3.05 (m, 2H), 3.16 (m, 1H), 3.31 (m, 1H), 6.54 (d, J=7.80 Hz, 2H), 7.49 (d, J=8.48 Hz, 2H), 7.66 (m, 4H), 7.87 (d, J=8.81 Hz, 1H), 8.10 (d, J=8.48 Hz, 1H), 8.22 (d, J=8.48 Hz, 1H), 8.33 (d, J=8.48 Hz, 2H); MS (DCI-NH3) [M+H]+ at 410.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07098222B2
Source dataset	uspto-grants-2006_08
ORD ID	ord-32cdb4973d2d4656b4410bc8f14c5413
Source note	uspto-grants-2006_08