Ammonia → (R)-6-(2-(2-methylpyrrolidin-1-yl)ethyl)-2-(4-(piperidin-1-yl)phenyl)quinoline

Participants

Role	Name	HCID	Charge
Reactant	Ammonia	HCID 222	—
Reactant	4'-Piperidinoacetophenone	HCID 82561	—
Reactant	1-[4-Methyl-2-(2-thienyl)-1,3-thiazol-5-yl]-1-ethanone	HCID 2744245	—
Product	(R)-6-(2-(2-methylpyrrolidin-1-yl)ethyl)-2-(4-(piperidin-1-yl)phenyl)quinoline	HCID 11524148	—

Reaction Steps

The title compound was prepared using the procedure described in Example 1G using 1-(4-piperidin-1-yl-phenyl)-ethanone for 1-(4-methyl-2-thiophen-2-yl-thiazol-5-yl)-ethanone. 1H NMR (300 MHz, CDCl3) δ 1.14 (d, J=5.42 Hz, 3H), 1.70 (m, 10H), 2.24 (m, 1H), 2.39 (m, 2H), 3.01 (m, 2H), 3.14 (m, 1H), 3.29 (m, 5H), 7.04 (d, J=8.81 Hz, 2H), 7.56 (dd, J=8.48, 2.03 Hz, 1H), 7.59 (s, 1H), 7.80 (d, J=8.48 Hz, 1H), 8.01–8.10 (m, 4H); MS (DCI-NH3) [M+H]+ at 400.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07098222B2
Source dataset	uspto-grants-2006_08
ORD ID	ord-0270a166b2234c0fbf846ad340ecf1ba
Source note	uspto-grants-2006_08