Hydrochloric Acid → 1-[[6-(2,4-difluorophenoxy)-1H-pyrazolo[5,4-d]pyrimidin-4-yl]amino]propan-2-ol

HRID 1133302Notes

Reaction equation

HRID 1133302 reaction equation
[CH3:33][OH:34].[ClH:32].[F:1][c:2]1[c:3]([O:4][c:5]2[n:6][c:7]([NH:22][CH2:23][CH:24]([CH3:25])[OH:26])[c:8]3[c:9]([n:10]2)[n:11]([CH2:14][O:15][CH2:16][CH2:17][Si:18]([CH3:19])([CH3:20])[CH3:21])[n:12][cH:13]3)[cH:27][cH:28][c:29]([F:31])[cH:30]1>>[F:1][c:2]1[c:3]([O:4][c:5]2[n:6][c:7]([NH:22][CH2:23][CH:24]([CH3:25])[OH:26])[c:8]3[c:9]([n:10]2)[nH:11][n:12][cH:13]3)[cH:27][cH:28][c:29]([F:31])[cH:30]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 688791801-[[6-(2,4-Difluorophenoxy)-1-(2-trimethylsilylethoxymethyl)pyrazolo[3,4-d]pyrimidin-4-yl]amino]propan-2-ol

Product 1

HCID 688798901-[[6-(2,4-difluorophenoxy)-1H-pyrazolo[5,4-d]pyrimidin-4-yl]amino]propan-2-ol

Sources & evidence

ORD record
ord-84bfcc01ba4a42758a16e645051a371d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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