Dichloromethane → 2-O-tert-butyl 7-O-ethyl 6-[2-(methoxycarbonylamino)-3-methylbutanoyl]-2,6-diazaspiro[3.4]octane-2,7-dicarboxylate

HRID 1133533Notes

Reaction equation

HRID 1133533 reaction equation
[CH2:1]1[N:2]([C:14](=[O:15])[O:16][C:17]([CH3:18])([CH3:19])[CH3:20])[CH2:3][C:4]12[CH2:5][NH:6][CH:7]([C:9](=[O:10])[O:11][CH2:12][CH3:13])[CH2:8]2.[CH3:45][O:46][C:47](=[O:48])[NH:49][CH:50]([CH:51]([CH3:52])[CH3:53])[C:54](=[O:55])[OH:56].[CH:57]([N:58]([CH2:59][CH3:60])[CH:61]([CH3:62])[CH3:63])([CH3:64])[CH3:65].[Cl:66][CH2:67][Cl:68].[P-:21]([F:22])([F:23])([F:24])([F:25])([F:26])[F:27].[n:28]1([O:29][C:30]([N:31]([CH3:32])[CH3:33])=[N+:34]([CH3:35])[CH3:36])[c:37]2[n:38][cH:39][cH:40][cH:41][c:42]2[n:43][n:44]1>>[CH2:1]1[N:2]([C:14](=[O:15])[O:16][C:17]([CH3:18])([CH3:19])[CH3:20])[CH2:3][C:4]12[CH2:5][N:6]([C:54]([CH:50]([NH:49][C:47]([O:46][CH3:45])=[O:48])[CH:51]([CH3:52])[CH3:53])=[O:55])[CH:7]([C:9](=[O:10])[O:11][CH2:12][CH3:13])[CH2:8]2

Participants

7

Reactant 6

HCID 6344DichloromethaneHCID 9886HexafluorophosphateHCID 81531DiisopropylethylamineHCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminiumHCID 138211012-((Methoxycarbonyl)amino)-3-methylbutanoic acidHCID 583130582-(Tert-butyl) 7-ethyl 2,6-diazaspiro[3.4]octane-2,7-dicarboxylate

Product 1

HCID 767570672-O-tert-butyl 7-O-ethyl 6-[2-(methoxycarbonylamino)-3-methylbutanoyl]-2,6-diazaspiro[3.4]octane-2,7-dicarboxylate

Sources & evidence

ORD record
ord-f8c18f008a7242d3a69957a8226b18f8
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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