Dichloromethane → 4-(3-Chloro-2-fluoroanilino)-6-[1-(methylsulfonyl)piperidin-3-yloxy]-7-methoxyquinazoline
Reaction equation
[CH2:43]([Cl:44])[Cl:45].[CH3:1][S:2]([Cl:3])(=[O:4])=[O:5].[CH:34]([N:35]([CH:36]([CH3:37])[CH3:38])[CH2:39][CH3:40])([CH3:41])[CH3:42].[Cl:6][c:7]1[c:8]([F:33])[c:9]([NH:10][c:11]2[n:12][cH:13][n:14][c:15]3[cH:16][c:17]([O:28][CH3:29])[c:18]([O:21][CH:22]4[CH2:23][NH:24][CH2:25][CH2:26][CH2:27]4)[cH:19][c:20]23)[cH:30][cH:31][cH:32]1>>[CH3:1][S:2](=[O:4])(=[O:5])[N:24]1[CH2:23][CH:22]([O:21][c:18]2[c:17]([O:28][CH3:29])[cH:16][c:15]3[n:14][cH:13][n:12][c:11]([NH:10][c:9]4[c:8]([F:33])[c:7]([Cl:6])[cH:32][cH:31][cH:30]4)[c:20]3[cH:19]2)[CH2:27][CH2:26][CH2:25]1Participants
5
Sources & evidence
- ORD record
- ord-7dda30efdb1549b2937cd3f5da945d16
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (7/10)
Reaction notes
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