HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1134088Generated: November 1, 2026
1,4-Dioxane → 6-[3-(3,4-Difluoro-phenyl)-5-hydroxymethyl-isoxazol-4-ylmethoxy]-N-(tetrahydro-pyran-4-yl)-nicotinamide
https://huagongshe.com/reaction/1134088
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | 4-Aminotetrahydropyran | HCID 419223 | — |
| Reactant | Trimethylaluminum | HCID 16682925 | — |
| Reactant | 6-[3-(3,4-Difluoro-phenyl)-5-hydroxymethyl-isoxazol-4-ylmethoxy]-nicotinic acid methyl ester | HCID 66718164 | — |
| Product | 6-[3-(3,4-Difluoro-phenyl)-5-hydroxymethyl-isoxazol-4-ylmethoxy]-N-(tetrahydro-pyran-4-yl)-nicotinamide | HCID 46928965 | — |
Provenance & Evidence
| DOI | 10.1039/C8SC04228D |
|---|
| Source dataset | Training data from https://doi.org/10.1039/C8SC04228D (7/10) |
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| ORD ID | ord-2abe72e9fc2546318ffe6f0260661a5f |
|---|
| Source note | Training data from https://doi.org/10.1039/C8SC04228D (7/10) |
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